The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address
limitations of traditional mental disorder diagnoses. These include arbitrary boundaries …

Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …

The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis.
Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD …

Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in
OPRM1, has been identified as a genome-wide significant association with OA and …

Abstract Background and Aims There is wide inter‐individual variability in response to the
treatment of alcohol use disorder (AUD) with the opioid receptor antagonist naltrexone. To …

Background Opioid use disorder (OUD) represents a large and pervasive global public
health challenge. Previous genetic studies have demonstrated the significant heritability of …

The human cerebral cortex contains many cell types that likely underwent independent
functional changes during evolution. However, cell-type–specific regulatory landscapes in …

Background The use of illicit substances is correlated, meaning that individuals who use one
illicit substance are more likely to also use another illicit substance. This association could …

We performed a multivariate gene-by-environment genome-wide interaction study (GEWIS)
of suicidality in 123,633 individuals using a covariance matrix based on 26 environments …