Metastatic disease from uveal melanoma: treatment options and future prospects
RD Carvajal, GK Schwartz, T Tezel, B Marr… - British Journal of …, 2017 - bjo.bmj.com
Uveal melanoma represents∼ 85% of all ocular melanomas and up to 50% of patients
develop metastatic disease. Metastases are most frequently localised to the liver and, as few …
develop metastatic disease. Metastases are most frequently localised to the liver and, as few …
Role of the p16 tumor suppressor gene in cancer.
WH Liggett Jr, D Sidransky - Journal of clinical oncology, 1998 - ascopubs.org
Since its discovery as a CDKI (cyclin-dependent kinase inhibitor) in 1993, the tumor
suppressor p16 (INK4A/MTS-1/CDKN2A) has gained widespread importance in cancer. The …
suppressor p16 (INK4A/MTS-1/CDKN2A) has gained widespread importance in cancer. The …
[图书][B] DeVita, Hellman, and Rosenberg's cancer: principles & practice of oncology
VT DeVita, TS Lawrence, SA Rosenberg - 2008 - books.google.com
Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
DE Ouelle, F Zindy, RA Ashmun, CJ Sherr - Cell, 1995 - Elsevier
The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-
dependent kinases CDK4 and CDK6 that blocks them from phosphorylating the …
dependent kinases CDK4 and CDK6 that blocks them from phosphorylating the …
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
L Zuo, J Weger, Q Yang, AM Goldstein, MA Tucker… - Nature …, 1996 - nature.com
Protein complexes consisting of a cyclin-dependent kinase (CDK4 or CDK6) and cyclin D
control passage through the G1 checkpoint of the cell cycle by phosphorylating the …
control passage through the G1 checkpoint of the cell cycle by phosphorylating the …
The p16INK4a/CDKN2A tumor suppressor and its relatives
M Ruas, G Peters - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1998 - Elsevier
In late 1993 and early 1994, two distinct lines of research converged on a new tumor
suppressor gene located on human chromosome 9p21. The órst report was of the existence …
suppressor gene located on human chromosome 9p21. The órst report was of the existence …
Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
M Hall, G Peters - Advances in cancer research, 1996 - Elsevier
Publisher Summary This chapter focuses on the genetic alterations of cyclins, cyclin
dependent kinases (Cdk), and Cdk inhibitors in human cancer. Contemporary research into …
dependent kinases (Cdk), and Cdk inhibitors in human cancer. Contemporary research into …
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
J Lukas, D Parry, L Aagaard, DJ Mann, J Bartkova… - Nature, 1995 - nature.com
D-TYPE cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote
progression through the Gl phase of the cell cycle1–6 by phosphorylating the retinoblastoma …
progression through the Gl phase of the cell cycle1–6 by phosphorylating the retinoblastoma …
Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence
Oncogene-induced senescence is characterized by a stable cell growth arrest, thus
providing a tumor suppression mechanism. However, the underlying mechanisms for this …
providing a tumor suppression mechanism. However, the underlying mechanisms for this …
Uveal melanoma: epidemiologic aspects
Melanomas of the ocular and adnexal structures comprise approximately 5% of all
melanomas. The majority (95%) of ocular melanomas are uveal in origin, whereas primary …
melanomas. The majority (95%) of ocular melanomas are uveal in origin, whereas primary …