Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs)
regulate the activity of small guanine nucleotide-binding (G) proteins to control cellular …

The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases.
To date, 22 human genes encoding at least 25 proteins have been described. The best …

Dendritic cells (DCs) are strong activators of primary T cell responses. Their priming ability is
acquired upon encounter with maturation stimuli. To identify the genes that are differentially …

The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that
transduce diverse intracellular signals leading to the activation of Rho GTPases. The …

The GTP hydrolases of the Rho/Rac family participate in the generation of coordinated
cellular responses to extracellular stimuli (52, 153). Their actions are essential to promote …

C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes,
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …

The Vav family proteins (Vav1, Vav2, Vav3) are cytoplasmic guanine nucleotide exchange
factors (GEFs) for Rho-family GTPases. T-cell antigen receptor (TCR) signalling results in …

In recent years, substantial progress has been made towards the identification of
intracellular signalling molecules that couple multi-subunit immune-recognition receptors …