The development of new resistance mechanisms in parasitic protozoa has prodded the
research community to step up their efforts to develop new tools to solve this problem. One …

There has been a very limited number of high-throughput screening campaigns carried out
with Leishmania drug targets. In part, this is due to the small number of suitable target genes …

Genetic studies of the protozoan parasite Plasmodium falciparum have been severely
limited by the inability to introduce or modify genes. In this paper we describe a system of …

Benznidazole is the frontline drug used against Trypanosoma cruzi, the causative agent of
Chagas disease. However, treatment failures are often reported. Here, we demonstrate that …

A trans-dominant mutational strategy was used to down-regulate trypanothione reductase
(TR) activity levels in Leishmania donovani, the causative agent of visceral leishmaniasis in …

Co-translational modification of eukaryotic proteins by N-myristoylation aids subcellular
targeting and protein-protein interactions. The enzyme that catalyzes this process, N …

The mammalian form of the protozoan parasite Leishmania mexicana contains high activity
of a cysteine proteinase (LmCPb) encoded on a tandem array of 19 genes (lmcpb) …

The American trypanosome Trypanosoma cruzi is exposed to toxic oxygen metabolites that
are generated by drug metabolism and immune responses in addition to those produced by …

In most aerobic organisms hemoperoxidases play a major role in H2O2-detoxification, but
trypanosomatids have been reported to lack this activity. Here we describe the properties of …

TcP2β ribosomal protein genes in Trypanosoma cruzi are encoded by four different loci, H6.
4, H1. 8, H1. 5 and H1. 3. All loci have a similar organization, except for H1. 8 that harbors …