Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

Three of the most fundamental questions in biology are how individual cells differentiate to
form tissues, how tissues function in a coordinated and flexible fashion and which gene …

The challenge of linking intergenic mutations to target genes has limited molecular
understanding of human diseases. Here we show that H3K27ac HiChIP generates high …

Naturally arising regulatory CD4+ T (Treg) cells, which specifically express the transcription
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …

Tumor necrosis factor α (TNF) is a potent pro-inflammatory cytokine that has deleterious
effect in some autoimmune diseases, which led to the use of anti-TNF drugs in some of …

Regulatory T (Treg) cell identity is defined by the lineage-specifying transcription factor (TF)
Foxp3. Here we examined mechanisms of Foxp3 function by leveraging naturally occurring …

The use of chimeric antigen receptor (CAR)-engineered regulatory T cells (Tregs) has
emerged as a promising strategy to promote immune tolerance. However, in conventional T …

The contribution of FOXP3-expressing naturally occurring regulatory T (Treg) cells to
common polygenic autoimmune diseases remains ambiguous. Here, we characterized …

Treg cells are critical regulators of immune homeostasis, and environment-driven Treg cell
differentiation into effector (e) Treg cells is crucial for optimal functioning. However, human …