A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

The size and surface area of the mammalian brain are thought to be critical determinants of
intellectual ability. Recent studies show that development of the gyrated human neocortex …

To understand the emergence of human higher cognition, we must understand its biological
substrate—the cerebral cortex, which considers itself the crowning achievement of evolution …

Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …

Neural stem cells (NSCs, B1 cells) are retained in the walls of the adult lateral ventricles but,
unlike embryonic NSCs, are displaced from the ventricular zone (VZ) into the subventricular …

The ability of cells to divide asymmetrically is essential for generating diverse cell types
during development. The past 10 years have seen tremendous progress in our …

Abstract In 1970 the Boulder Committee described the basic principles of the development
of the CNS, derived from observations on the human embryonic cerebrum. Since then …

Stem cells self-renew but also give rise to daughter cells that are committed to lineage-
specific differentiation. To achieve this remarkable task, they can undergo an intrinsically …

The Notch pathway is often regarded as a developmental pathway, but components of Notch
signalling are expressed and active in the adult brain. With the advent of more sophisticated …