Computer‐Aided Design of VEGFR‐2 Inhibitors as Anticancer Agents: A Review
AI Uba - Journal of Molecular Recognition, 2024 - Wiley Online Library
Due to its intricate molecular and structural characteristics, vascular endothelial growth
factor receptor 2 (VEGFR‐2) is essential for the development of new blood vessels in …
factor receptor 2 (VEGFR‐2) is essential for the development of new blood vessels in …
Characterization of Plant-Derived Natural Inhibitors of Dipeptidyl Peptidase-4 as Potential Antidiabetic Agents: A Computational Study
Diabetes, characterized by elevated blood sugar levels, poses significant health and
economic risks, correlating with complications like cardiovascular disease, kidney failure …
economic risks, correlating with complications like cardiovascular disease, kidney failure …
Design, synthesis, in vitro, and in silico studies of new thiadiazol derivatives as promising VEGFR-2 inhibitors and apoptosis inducers
HA Mahdy, H Elkady, WE Elgammal… - Journal of Molecular …, 2024 - Elsevier
The presented study reports the synthesis, in silico and in vitro evaluations of a series of
novel thiadiazole derivatives designed with the pharmacophoric features of Vascular …
novel thiadiazole derivatives designed with the pharmacophoric features of Vascular …
Microscopic solvent-solute interactions, reactivity studies, structure properties and anti cancer activity of 1-(1-benzofuran-5-yl)-N-methylbutan-2-amine
KM Potla, S Sakthivel, JNC Mishma, NS Alharbi… - Journal of Molecular …, 2024 - Elsevier
Cancer continues to be a major threat to mankind, as seen by the 19.3 million people who
received treatment for the disease in 2020. The study employed quantum mechanical …
received treatment for the disease in 2020. The study employed quantum mechanical …
Design, Synthesis, and Quantum Chemical Calculations of Triazole-Based Aroylhydrazone Molecules: Dual Assessment of Antioxidant Properties via in vitro and in …
In this study, five novel Triazole-Based Aroylhydrazone compounds (6a-e) were synthesized
in high yields (87-79%), starting from deferasirox which has known iron chelator, and …
in high yields (87-79%), starting from deferasirox which has known iron chelator, and …
New Thieno[2,3-d]pyrimidines as Anticancer VEGFR-2 Inhibitors with Apoptosis Induction: Design, Synthesis, and Biological and In Silico Studies
Background Vascular endothelial growth factor receptor-2 (VEGFR-2) is a critical protein
involved in tumor progression, making it an attractive target for cancer therapy. Objective …
involved in tumor progression, making it an attractive target for cancer therapy. Objective …
Synthesis, crystal structure, antioxidant activity and molecular docking studies of 2-(1-(3-methyl-1-oxo-1, 2, 3, 4-tetrahydronaphthalen-2-yl) ethyl) malononitrile
R Bouzammit, I Lakkab, Y Kanzouai, M Chalkha… - Journal of Molecular …, 2024 - Elsevier
In the current study, we report the synthesis, structural determination, and both in vitro and in
silico antioxidant assessment of 2-(1-(3-methyl-1-oxo-1, 2, 3, 4-tetrahydronaphthalen-2-yl) …
silico antioxidant assessment of 2-(1-(3-methyl-1-oxo-1, 2, 3, 4-tetrahydronaphthalen-2-yl) …