The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …

Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

Background Obesity surgery is acknowledged as a highly effective therapy for morbidly
obese patients. Beneficial short‐term effects on common comorbidities are practically …

Intestinal transporters are crucial determinants in the oral absorption of many drugs. We
therefore studied the mRNA expression (N= 33) and absolute protein content (N= 10) of …

P-glycoprotein is the product of the ABCB1 [also known as multidrug resistance 1 (MDR1)]
gene. It translocates a broad variety of xenobiotics out of cells. P-glycoprotein was first …

The bioavailability of drugs from oral formulations is influenced by many physiological
factors including gastrointestinal fluid composition, pH and dynamics, transit and motility …

Importance of the field: The use of traditional medicines of natural origin is being
encouraged for the treatment of chronic disorders, as synthetic drugs in such cases may …

Most marketed drugs are administered orally, despite the complex process of oral
absorption that is difficult to predict. Oral bioavailability is dependent on the interplay …