Gene expression in members of the family Bacillaceae becomes compartmentalized after
the distinctive, asymmetrically located sporulation division. It involves complete …

The soil bacterium Bacillus subtilis uses two different developmental pathways to induce
sporulation and the development of genetic competence. Although they use the same …

Dividing cells must coordinate cell cycle events to ensure genetic stability. Here we identify
an essential two-component signal transduction protein that controls multiple events in the …

The spo0J gene of Bacillus subtilis is required for the initiation of sporulation. We show that
the sporulation defect caused by null mutations in spo0J is suppressed by a null mutation in …

The bacterium Bacillus subtilis produces the DNA integrity scanning protein (DisA), a
checkpoint protein that delays sporulation in response to DNA damage. DisA scans the …

From microbes to multicellular eukaryotic organisms, all cells contain pathways responsible
for genome maintenance. DNA replication allows for the faithful duplication of the genome …

Bacterial genomes contain 250 to 500 essential genes, as suggested by single gene
disruptions and theoretical considerations. If this view is correct, the remaining nonessential …

We identified a signaling pathway that prevents initiation of sporulation in Bacillus subtilis
when replication initiation is impaired. We isolated mutations that allow a replication …

Multiple physiological and environmental signals are needed to initiate endospore formation
in Bacillus subtilis. One key event controlling sporulation is activation of the Spo0A …

The spo0E locus of Bacillus subtilis codes for a negative regulator of sporulation that, when
overproduced, represses sporulation and, if deleted, results in inappropriate timing of …