Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria

SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

F Lennartz, Y Adams, A Bengtsson, RW Olsen… - Cell host & …, 2017 - cell.com
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …

Severe malaria: what's new on the pathogenesis front?

SC Wassmer, GER Grau - International journal for parasitology, 2017 - Elsevier
Plasmodium falciparum causes the most severe and fatal form of malaria in humans with
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …

Sticking for a cause: the falciparum malaria parasites cytoadherence paradigm

WC Lee, B Russell, L Rénia - Frontiers in immunology, 2019 - frontiersin.org
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …

Malaria-associated acute kidney injury in African children: prevalence, pathophysiology, impact, and management challenges

A Batte, Z Berrens, K Murphy, I Mufumba… - … of Nephrology and …, 2021 - Taylor & Francis
Acute kidney injury (AKI) is emerging as a complication of increasing clinical importance
associated with substantial morbidity and mortality in African children with severe malaria …

Cerebral malaria is associated with differential cytoadherence to brain endothelial cells

J Storm, JS Jespersen, KB Seydel… - EMBO Molecular …, 2019 - embopress.org
Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Linking EPCR-binding PfEMP1 to brain swelling in pediatric cerebral malaria

A Kessler, S Dankwa, M Bernabeu, V Harawa… - Cell host & …, 2017 - cell.com
Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM). However,
the mechanisms leading to swelling remain poorly defined. Here, we combined …

[HTML][HTML] Determinants of brain swelling in pediatric and adult cerebral malaria

PK Sahu, FJ Duffy, S Dankwa, M Vishnyakova… - JCI insight, 2021 - ncbi.nlm.nih.gov
Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in
children. To investigate features associated with brain swelling in malaria, we performed …