Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria
SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …
the world's population at risk of Plasmodium infections. The development of an effective …
Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria
F Lennartz, Y Adams, A Bengtsson, RW Olsen… - Cell host & …, 2017 - cell.com
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …
Severe malaria: what's new on the pathogenesis front?
SC Wassmer, GER Grau - International journal for parasitology, 2017 - Elsevier
Plasmodium falciparum causes the most severe and fatal form of malaria in humans with
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …
Sticking for a cause: the falciparum malaria parasites cytoadherence paradigm
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …
Malaria-associated acute kidney injury in African children: prevalence, pathophysiology, impact, and management challenges
A Batte, Z Berrens, K Murphy, I Mufumba… - … of Nephrology and …, 2021 - Taylor & Francis
Acute kidney injury (AKI) is emerging as a complication of increasing clinical importance
associated with substantial morbidity and mortality in African children with severe malaria …
associated with substantial morbidity and mortality in African children with severe malaria …
Cerebral malaria is associated with differential cytoadherence to brain endothelial cells
J Storm, JS Jespersen, KB Seydel… - EMBO Molecular …, 2019 - embopress.org
Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …
Pathogenicity and virulence of malaria: Sticky problems and tricky solutions
IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …
each year, concentrated in Africa and in young children, but much of the world's population …
Linking EPCR-binding PfEMP1 to brain swelling in pediatric cerebral malaria
A Kessler, S Dankwa, M Bernabeu, V Harawa… - Cell host & …, 2017 - cell.com
Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM). However,
the mechanisms leading to swelling remain poorly defined. Here, we combined …
the mechanisms leading to swelling remain poorly defined. Here, we combined …
[HTML][HTML] Determinants of brain swelling in pediatric and adult cerebral malaria
Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in
children. To investigate features associated with brain swelling in malaria, we performed …
children. To investigate features associated with brain swelling in malaria, we performed …