Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Spinal cord injury (SCI) lesions present diverse challenges for repair strategies.
Anatomically complete injuries require restoration of neural connectivity across lesions …

Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are
widely regarded as causal in this failure. Here, using three genetically targeted loss-of …

Recovery from spinal cord injury (SCI) remains an unsolved problem. As a major component
of the SCI lesion, the glial scar is primarily composed of scar-forming astrocytes and plays a …

Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he
correctly surmised that microglia in pathologic central nervous system (CNS) were …

Animal studies are now showing the exciting potential to achieve significant functional
recovery following central nervous system (CNS) injury by manipulating both the inefficient …

Damage to the adult CNS often leads to persistent deficits due to the inability of mature
axons to regenerate after injury. Mounting evidence suggests that the glial environment of …

In the central nervous system, NG2‐glia represent a neural cell population that is distinct
from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to …

NG2 cells (also known as polydendrocytes) are a population of CNS cells that are distinct
from neurons, mature oligodendrocytes, astrocytes and microglia. They can be identified by …

In the central nervous system, oligodendrocytes produce myelin sheaths that enwrap
neuronal axons to provide trophic support and increase conduction velocity. New …