Cyclodextrin‐based formulations: a non‐invasive platform for targeted drug delivery
C Muankaew, T Loftsson - Basic & clinical pharmacology & …, 2018 - Wiley Online Library
Cyclodextrins (CD s) are recognized as promising pharmaceutical excipients due to their
unique ability to form water‐soluble inclusion complexes with various poorly soluble …
unique ability to form water‐soluble inclusion complexes with various poorly soluble …
The solubility–permeability interplay and oral drug formulation design: Two heads are better than one
Poor aqueous solubility is a major challenge in today's biopharmaceutics. While solubility-
enabling formulations can significantly increase the apparent solubility of the drug, the …
enabling formulations can significantly increase the apparent solubility of the drug, the …
Screening the possible anti-cancer constituents of Hibiscus rosa-sinensis flower to address mammalian target of rapamycin: an in silico molecular docking, HYDE …
One of the most common malignancies diagnosed and the leading cause of death for cancer-
stricken women globally is breast cancer. The molecular subtype affects therapy options …
stricken women globally is breast cancer. The molecular subtype affects therapy options …
Discovery of new quinoxaline-2 (1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation
VEGF/VEGFR2 pathway is the crucial therapeutic target in the treatment of cancer. So that, a
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
Discovery of potential mTOR inhibitors from Cichorium intybus to find new candidate drugs targeting the pathological protein related to the breast cancer: an …
Breast cancer is the most common malignancy among women. It is a complex condition with
many subtypes based on the hormone receptor. The mammalian target of the rapamycin …
many subtypes based on the hormone receptor. The mammalian target of the rapamycin …
[HTML][HTML] Best practices in current models mimicking drug permeability in the gastrointestinal tract-An UNGAP review
The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …
The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and in silico mechanistic studies as dual DNA gyrase and …
MH El-Shershaby, KM El-Gamal, AH Bayoumi… - New Journal of …, 2021 - pubs.rsc.org
The resistance of pathogenic microbes to currently available antimicrobial agents has been
considered a global alarming concern. Hence, close attention should be paid to the …
considered a global alarming concern. Hence, close attention should be paid to the …
Pharmacophore‐linked pyrazolo[3,4‐d]pyrimidines as EGFR‐TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies
Targeting the epidermal growth factor receptors (EGFRs) with small inhibitor molecules has
been validated as a potential therapeutic strategy in cancer therapy. Pyrazolo [3, 4‐d] …
been validated as a potential therapeutic strategy in cancer therapy. Pyrazolo [3, 4‐d] …
Applications of polymers as pharmaceutical excipients in solid oral dosage forms
N Debotton, A Dahan - Medicinal research reviews, 2017 - Wiley Online Library
Over the last few decades, polymers have been extensively used as pharmaceutical
excipients in drug delivery systems. Pharmaceutical polymers evolved from being simply …
excipients in drug delivery systems. Pharmaceutical polymers evolved from being simply …
Rationale design, synthesis, cytotoxicity evaluation, and in silico mechanistic studies of novel 1, 2, 3-triazoles with potential anticancer activity
A new set of 1, 2, 3-triazoles was designed and synthesized to evaluate their potential to
inhibit the growth of cancer cells. Thiazole, thiazolone, and hydrazine as effective fragments …
inhibit the growth of cancer cells. Thiazole, thiazolone, and hydrazine as effective fragments …