Objective: This review details the agents for fluorescence-guided nerve imaging in both
preclinical and clinical use to identify factors important in selecting nerve-specific fluorescent …

Regeneration of damaged peripheral nerves remains one of the main challenges of
neurosurgery and regenerative medicine, a nerve functionality is rarely restored, especially …

Pro-regenerative macrophages are well known for their role in promoting tissue repair;
however, their specific roles in promoting regeneration of the injured nerve are not well …

Repair of large nerve defects with acellular nerve allografts (ANAs) is an appealing
alternative to autografting and allotransplantation. ANAs have been shown to be similar to …

Acellular nerve allografts (ANAs) and other nerve constructs do not reliably facilitate axonal
regeneration across long defects (> 3 cm). Causes for this deficiency are poorly understood …

Despite advances in surgery, patients with nerve injuries frequently have functional deficits.
We previously demonstrated in a rat model that daily electrical muscle stimulation (EMS) …

Acellular nerve allografts (ANAs) are used clinically to bridge nerve gaps but these grafts,
lacking Schwann cells and therapeutic levels of neurotrophic factors, do not support …

Nerve graft reconstruction of gap defects may result in poor clinical outcomes, particularly
with long regeneration distances. Electrical stimulation (ES) of nerves may improve …

PURPOSE: To investigate the ability of a supercharge end-to-side (SETS) nerve transfer to
augment the effect of regenerating native axons in an incomplete rodent sciatic nerve injury …

The use of growth factors, such as glial cell line-derived neurotrophic factor (GDNF), for the
treatment of peripheral nerve injury has been useful in promoting axon survival and …