TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …

This white paper discusses prospects for advancing hyperpolarization technology to better
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …

We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the
deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation …

Obesity poses a severe threat to human health, including the increased prevalence of
hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and …

Transcription factors (TFs) regulate gene expression by binding to DNA sequences and
modulating transcriptional activity through their effector domains. Despite the central role of …

Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most
aggressive human solid malignancies known. NMC is driven by the creation of a …

Detecting and targeting precancerous cells in noncancerous tissues is a major challenge for
cancer prevention. Massive stabilization of mutant p53 (mutp53) proteins is a cancer-specific …

Glucose is the key source for most organisms to provide energy, as well as the key source
for metabolites to generate building blocks in cells. The deregulation of glucose …