Interferons are cytokines that have antiviral, antiproliferative and immunomodulatory effects.
Because of these important properties, in the past two decades, major research efforts have …

The interferons (IFNs) were originally described over 50 years ago, identified by their ability
to confer viral resistance to cells. We now know that they are much more than just anti‐viral …

Recombinant interferon‐α (IFN‐α) was approved by regulatory agencies in many countries
in 1986. As the first biotherapeutic approved, IFN‐α paved the way for the development of …

Type I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant
transformation, tumor progression, and response to therapy. On the one hand, robust, acute …

In the context of OA disease, NF-κB transcription factors can be triggered by a host of stress-
related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM …

Soy isoflavones have been identified as dietary components having an important role in
reducing the incidence of breast and prostate cancers in Asian countries. Genistein, the …

Interferons (IFNs) elicit multifaceted effects in host innate defence. Accumulating evidence
revealed that not only the first identified Jak‐Stat pathway but also other newly found …

The type I interferons (IFNs) are pleiotropic cytokines that regulate many different cellular
functions. The major signaling pathway activated by type I IFNs involves sequential …

Abstract Type I interferons (IFN-Is) are a group of molecules with pleiotropic effects on the
immune system forming a crucial link between innate and adaptive immune responses …

Diet has been implicated to play an important role in cancers. Epidemiological studies have
revealed that Asians, who consume a traditional diet high in soy products, have relatively …