The increase in recent scientific studies on cancer biomarkers has brought great new
insights into the field. Moreover, novel technological breakthroughs such as long read …

RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …

Aberrant DNA methylation patterns may be the earliest somatic genome changes in prostate
cancer. Using real-time methylation-specific PCR, we assessed the extent of …

Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations.
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …

In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …

Ras proteins function as signal transducers and are mutationally activated in many human
cancers. In 1993, Raf was identified as a key downstream effector of Ras signaling, and it …

Tumour suppressor gene inactivation is critical to the pathogenesis of cancers; such loss of
function may be mediated by irreversible processes such as gene deletion or mutation …

Ovarian cancer is a disease with a poor prognosis and little progress has been made to
improve treatment. It is now recognized that there are several histotypes of ovarian cancer …

Hypomethylation of some portions of the genome and hypermethylation of others are very
frequent in human cancer. The hypomethylation often involves satellite 2 (Sat2) DNA in the …

Little is known about epigenetic silencing of genes by promoter hypermethylation in lobular
breast cancers. The promoter methylation status of 5 cancer‐related genes (RASSF1A, HIN …