The status and prospects of Epstein–Barr virus prophylactic vaccine development

C Sun, X Chen, Y Kang, M Zeng - Frontiers in Immunology, 2021 - frontiersin.org
Epstein–Barr virus (EBV) is a human herpesvirus that is common among the global
population, causing an enormous disease burden. EBV can directly cause infectious …

Epidemiology of nasopharyngeal carcinoma: current insights and future outlook

ZY Su, PY Siak, YY Lwin, SC Cheah - Cancer and Metastasis Reviews, 2024 - Springer
Nasopharyngeal carcinoma (NPC) is characterised by its remarkable geographical and
ethnic distribution. The interplay between genetic susceptibility, environmental exposures …

Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection

J Hong, L Zhong, L Liu, Q Wu, W Zhang, K Chen… - Cell Reports …, 2023 - cell.com
Epstein-Barr virus (EBV) is closely associated with cancer, multiple sclerosis, and post-acute
coronavirus disease 2019 (COVID-19) sequelae. There are currently no approved …

A lipid-based LMP2-mRNA vaccine to treat nasopharyngeal carcinoma

M Guo, X Duan, X Peng, Z Jin, H Huang, W Xiao… - Nano Research, 2023 - Springer
Nasopharyngeal carcinoma (NPC) is a serious and highly invasive epithelial malignancy
that is closely associated with Epstein—Barr virus (EBV). Due to the lack of therapeutic …

A cocktail nanovaccine targeting key entry glycoproteins elicits high neutralizing antibody levels against EBV infection

L Zhong, W Zhang, H Liu, X Zhang, Z Yang… - Nature …, 2024 - nature.com
Epstein-Barr virus (EBV) infects more than 95% of adults worldwide and is closely
associated with various malignancies. Considering the complex life cycle of EBV …

Interferon-induced transmembrane protein-1 competitively blocks Ephrin receptor A2-mediated Epstein–Barr virus entry into epithelial cells

Y Yang, T Ding, Y Cong, X Luo, C Liu, T Gong… - Nature …, 2024 - nature.com
Epstein–Barr virus (EBV) can infect both B cells and epithelial cells (ECs), causing diseases
such as mononucleosis and cancer. It enters ECs via Ephrin receptor A2 (EphA2). The …

A high-throughput neutralizing assay for antibodies and sera evaluation against Epstein-Barr virus

L Zhong, C Krummenacher, W Zhang, J Hong, Q Feng… - Virology Journal, 2022 - Springer
Abstract Background Epstein-Barr virus (EBV) is a wide-spread human herpesvirus that is
highly associated with infectious mononucleosis and several malignancies. Evaluation of …

Potent human monoclonal antibodies targeting Epstein-Barr virus gp42 reveal vulnerable sites for virus infection

GX Zhao, XY Fang, GL Bu, C Sun, T Li, C Xie… - Cell Reports …, 2024 - cell.com
Epstein-Barr virus (EBV) is linked to various malignancies and autoimmune diseases,
posing a significant global health challenge due to the lack of specific treatments or …

Evaluation of serum Epstein–Barr virus envelope glycoproteins antibodies and their association with systemic autoimmune diseases

HL Li, LY Zhong, YF Kang, YL Yang… - Journal of Medical …, 2024 - Wiley Online Library
Systemic autoimmune diseases (SADs) are a growing spectrum of autoimmune disorders
that commonly affect multiple organs. The role of Epstein–Barr virus (EBV) infection or …