Filamentous fungi produce a multitude of low molecular weight bioactive compounds. The
increasing number of fungal genome sequences impressively demonstrated that their …

Terpenoids represent a diverse class of molecules that provide a wealth of opportunities to
address many human health and societal issues. The expansive array of structures and …

Microbial-derived natural products provide the foundation for most of the chemotherapeutic
arsenal available to contemporary medicine. In the face of a dwindling pipeline of new lead …

Bioformulations for plant growth promotion continue to inspire research and development in
many fields. Increase in soil fertility, plant growth promotion, and suppression of …

Covering: 2007 to 2011. Previous review: Nat. Prod. Rep., 2007, 24, 750 Common to all
FASs, PKSs and NRPSs is a remarkable component, the acyl or peptidyl carrier protein …

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways -
Natural Product Reports (RSC Publishing) DOI:10.1039/B801747F Royal Society of Chemistry …

Fatty acid synthase (FAS), polyketide synthase (PKS), and nonribosomal peptide synthetase
(NRPS) modular biosynthetic enzymes are responsible for the production of a multitude of …

The ongoing exponential growth of DNA sequence data will lead to the discovery of many
natural-product biosynthesis pathways by genome mining for which no actual product has …

Every year about 7 million people die from of various types of cancer, making this disease
responsible for 12.5% of deaths worldwide. Consequently, there is an overwhelming …

Combinatorial biosynthesis can refer to any strategy for the genetic engineering of natural
product biosynthesis to obtain new molecules, including the use of genetics for medicinal …