Highlights•Non-conventional feedstocks can contribute to a circular chemical industry.•Non-
conventional feedstocks open stoichiometric opportunities for niche applications.•Plastic …

Over the last few decades, increasing concerns regarding fossil fuel depletion and
excessive CO2 emissions have led to extensive fundamental studies and industrial trials …

Currently, the biological production of L-malic acid (L-MA) is mainly based on the
fermentation of filamentous fungi at near-neutral pH, but this process requires large amounts …

CRISPR/Cas9 system exploits the concerted action of Cas9 nuclease and programmable
single guide RNA (sgRNA), and has been widely used for genome editing. The Cas9 …

L-malic acid (MA) is a vital platform chemical with huge market demand because of its broad
industrial applications. A cell factory for MA production was engineered by strengthening the …

The impact of cultivation strategy on the cost of recombinant protein production is crucial for
defining cost-effective bioreactor operation conditions. This paper presents a methodology …

In the 1950s, the idea of a single harmonized list of food additives for the European Union
arose. Already in 1962, the E-classification system, a robust food safety system intended to …

As an alternative to petrochemical synthesis, well-established industrial microbes, such as
Escherichia coli, are employed to produce a wide range of chemicals, including dicarboxylic …

Uridine is a kind of pyrimidine nucleoside that has been widely applied in the
pharmaceutical industry. Although microbial fermentation is a promising method for …

Background The bioconversion of phytosterols into high value-added steroidal
intermediates, including the 9 α-hydroxy-4-androstene-3, 17-dione (9-OHAD) and 22 …