The role of epidermal growth factor receptor family of receptor tyrosine kinases in mediating diabetes-induced cardiovascular complications

BA Shraim, MO Moursi, IF Benter, AM Habib… - Frontiers in …, 2021 - frontiersin.org
Diabetes mellitus is a major debilitating disease whose global incidence is progressively
increasing with currently over 463 million adult sufferers and this figure will likely reach over …

Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes

VK Pandey, A Mathur, P Kakkar - Life sciences, 2019 - Elsevier
Endoplasmic reticulum (ER) is a crucial single membrane organelle that acts as a quality
control system for cellular proteins as it is intricately involved in their synthesis, folding and …

Exploring the mechanisms underlying the therapeutic effect of Salvia miltiorrhiza in diabetic nephropathy using network pharmacology and molecular docking

L Zhang, L Han, X Wang, Y Wei, J Zheng… - Bioscience …, 2021 - portlandpress.com
The mechanisms underlying the therapeutic effect of Salvia miltiorrhiza (SM) on diabetic
nephropathy (DN) were examined using a systematic network pharmacology approach and …

BM-MSCs alleviate diabetic nephropathy in male rats by regulating ER stress, oxidative stress, inflammation, and apoptotic pathways

T Khamis, A Abdelkhalek, H Abdellatif… - Frontiers in …, 2023 - frontiersin.org
Introduction: Diabetic nephropathy (DN), a chronic kidney disease, is a major cause of end-
stage kidney disease worldwide. Mesenchymal stem cells (MSCs) have become a …

Based on network pharmacology tools to investigate the molecular mechanism of Cordyceps sinensis on the treatment of diabetic nephropathy

Y Li, L Wang, B Xu, L Zhao, L Li, K Xu… - Journal of diabetes …, 2021 - Wiley Online Library
Background. Diabetic nephropathy (DN) is one of the most common complications of
diabetes mellitus and is a major cause of end‐stage kidney disease. Cordyceps sinensis …

The Role of Oxidative Stress in Tumorigenesis and Progression

K Li, Z Deng, C Lei, X Ding, J Li, C Wang - Cells, 2024 - mdpi.com
Oxidative stress refers to the imbalance between the production of reactive oxygen species
(ROS) and the endogenous antioxidant defense system. Its involvement in cell senescence …

MicroRNAs in the progress of diabetic nephropathy: A systematic review and meta‐analysis

L Wang, Y Gao, B Song, G Yu, H Chen… - Evidence‐Based …, 2019 - Wiley Online Library
Background. We conducted a systematic review and meta‐analysis of existing literature to
evaluate the different outcomes of microRNAs (miRNAs) in diabetic nephropathy (DN) …

Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury

Y Gu, F Huang, Y Wang, C Chen, S Wu, S Zhou… - Journal of translational …, 2018 - Springer
Abstract Background Ischemia–reperfusion (I/R)-induced acute kidney injury (AKI) not only
prolongs the length of hospital stay, but also seriously affects the patient's survival rate …

Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy

R Van Krieken, N Mehta, T Wang, M Zheng, R Li… - Journal of Biological …, 2019 - ASBMB
The 78-kDa glucose-regulated protein (GRP78) is a well-established endoplasmic reticulum
(ER)-resident chaperone that maintains protein homeostasis and regulates the unfolded …

A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice

J de Carvalho Marchesin, LS Celiberto… - Journal of functional …, 2018 - Elsevier
This work investigates the effect of a soy-based probiotic drink (Enterococcus faecium CRL
183 and Bifidobacterium longum ATCC 15707) on the fecal microbiota composition, body …