Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Patients who are diagnosed with osteosarcoma (OS) today receive the same therapy that
patients have received over the last 4 decades. Extensive efforts to identify more effective or …

Dynamic network biomarkers (DNB) can identify the critical state or tipping point of a
disease, thereby predicting rather than diagnosing the disease. However, it is difficult to …

Background Glutamate metabotropic receptors (GRM) play a variety of roles in neuronal
cells. However, their clinical significance and biological functions in breast cancer remain …

The glutamate metabotropic receptor 4 (GRM4) locus is linked to susceptibility to human
osteosarcoma, through unknown mechanisms. We show that Grm4−/− gene–targeted mice …

Osteosarcoma, a malignant primary bone tumor most commonly diagnosed in children and
adolescents, has a poorly understood genetic etiology. Genome-wide association studies …

High-grade osteosarcoma (HGOS) is a very aggressive bone tumor which primarily affects
adolescents and young adults. Although not advanced as is the case for other cancers …

Glioblastoma multiforme (GBM) is the most lethal glioma variant in the adult brain and
among the deadliest of human cancers. Increasing evidence has shown that metabotropic …

This study is aimed to investigate the role of microRNA-144 (miR-144) in osteosarcoma cell
line F5M2 proliferation, apoptosis, invasion, and metastasis. Between 2007 and 2014, 66 …

To investigate correlations between excision repair cross-complementation group 1
(ERCC1) and 2 (ERCC2) polymorphisms and osteosarcoma prognosis, we conducted a …