Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

I Akhlaghipour, AR Bina, MR Mogharrabi, A Fanoodi… - Human Genomics, 2022 - Springer
Diabetes is a chronic metabolic disorder that leads to the dysfunction of various tissues and
organs, including eyes, kidneys, and cardiovascular system. According to the World Health …

Genetic screening for pathogenic variants in type 2 diabetes of the Arab Gulf population: A systematic review and meta-analysis

KNJ Musafer, M Rava, MBS Al-Shuhaib - International Journal of Diabetes …, 2024 - Springer
Abstract Objective The Arab Gulf is highly vulnerable to T2DM and its serious
consequences. The manner in which these populations respond to such alterations in their …

Involvement of TCF7L2 in generation of morphine-induced antinociceptive tolerance and hyperalgesia by modulating TLR4/NF-κB/NLRP3 in microglia

J Chen, G Wang, T Sun, C Ma, X Huo… - Toxicology and Applied …, 2021 - Elsevier
Morphine is an opioid agonist and a nonselective mu, kappa and delta receptor agonist. It is
a commonly used analgesic drug for the treatment of acute and chronic pain as well as …

Single nucleotide polymorphism rs7908486 of the tcf7l2 gene is highly associated with obesity in the Iraqi population

AK Mohammed, TM Al-Thuwaini… - Archives of Biological …, 2021 - serbiosoc.org.rs
This study was conducted to assess the possible association between polymorphisms of the
transcription factor 7-like 2 (TCF7L2) gene and obese Iraqi adults. DNA was obtained from …

TCF7L2 and FTO Polymorphisms Are Associated with Type 2 Diabetes Mellitus Risk in Kuwait

N Chaudhary, F Alawadhi, A Al-Serri… - Medical Principles and …, 2024 - karger.com
Objective: Despite the high prevalence of type 2 diabetes mellitus (T2DM) and obesity in the
region, reports are limited on genetic risk factors associated with T2DM risk in Kuwait. Our …

Association Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China

H Yu, L Xu, H Liu, J Huang, L Luo… - BioMed Research …, 2021 - Wiley Online Library
Objective. This study is aimed at analyzing the relationship between leptin (LEP) signaling
pathway and type 2 diabetes mellitus (T2DM) and at providing support for molecular genetic …

Assessment of the relationship of transcription factor 7-like 2 rs4506565 (T/A) variant with type 2 diabetes in Iraqi Arab patients

AS Abdullah, SK Ali - Meta Gene, 2022 - Elsevier
Researchers have consistently linked some TCF7L2 gene variations, such as rs7903146,
rs12255372, and rs11255372, to Type 2 diabetes mellitus (T2DM) in numerous populations …

Investigação da relação de marcadores moleculares nos genes TCF2L7, ADBR3 e FTO com os parâmetros bioquímicos e antropométricos

RF Pinheiro, BEG Teixeira… - Revista Eletrônica …, 2023 - acervomais.com.br
Objetivo: Selecionar e analisar de maneira sistemática, trabalhos nos quais a avaliação da
correlação entre polimorfismos e medidas antropométricas e bioquímicas eram discutidas …

Association Between Type 2 Diabetes Mellitus and TCF7L2 And FTO Gene Variants Among Upper Egyptian Population

MH Maghraby, R Fathy, SAR Atta… - The Egyptian Journal …, 2022 - journals.ekb.eg
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder caused by a complex
interaction of genetic and environmental variables. T2DM is associated with transcription …