One-third of the world's population infected tuberculosis (TB), and more than 1 million
deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis …

Highlights•DNA topoisomerases are key targets for antibacterial and anticancer
chemotherapy.•TB topo I is validated as an antibacterial target.•Inhibitors that target TB topo I …

New antibiotics with either a novel mode of action or novel mode of inhibition are urgently
needed to overcome the threat of drug-resistant tuberculosis (TB). The present study profiles …

DNA gyrase and topoisomerase IV are the bacterial type IIA topoisomerases. These are
ubiquitous nucleic acid-dependent nanomachines, essential to cell life, that solve DNA …

Bacterial resistance is inevitable and is a growing concern. It can be addressed only by
discovery and development of new agents. However the discovery and development of new …

Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of
drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control …

A novel pyrazolopyridone class of inhibitors was identified from whole cell screening against
Mycobacterium tuberculosis (Mtb). The series exhibits excellent bactericidality in vitro …

Highlights•Compounds with efficacy in animal models are emphasized.•Twelve compounds
from three mechanistic classes are highlighted.•Results tabulated for microbiological and PK …

A novel series of substituted thiazolo [5, 4-b] pyridine analogues were rationally designed
and synthesized via a multi-step synthetic pathway, including Suzuki cross-coupling …

New drugs to treat drug-resistant tuberculosis are urgently needed. Extensively drug-
resistant and probably the totally drug-resistant tuberculosis strains are resistant to …