The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …

The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

Hydrophobic signal sequences target secretory polypeptides to a protein-conducting
channel formed by a heterotrimeric membrane protein complex, the prokaryotic SecY or …

Co-translational protein targeting to the endoplasmic reticulum (ER), represents an
evolutionary-conserved mechanism to target proteins into the secretory pathway. In this …

Gram negative bacteria possess a large variety of protein transport systems, by which
proteins that are synthesised in the cytosol are exported to destinations in the cell envelope …

Bacterial YidC, an evolutionally conserved membrane protein, functions as a membrane
protein chaperone in cooperation with the Sec translocon and as an independent insertase …

The SecY/61 complex forms the protein-channel component of the ubiquitous protein
secretion and membrane protein insertion apparatus. The bacterial version SecYEG …

The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …

Many secretory proteins are targeted by signal sequences to a protein-conducting channel,
formed by prokaryotic SecY or eukaryotic Sec61 complexes, and are translocated across the …

Highlights•Advances in cryo-electron microscopy allow analysis of low abundance native
complexes.•Near-atomic resolution structures of intermediates in co-translational …