In vitro hepatocyte models represent very useful systems in both fundamental research and
various application areas. Primary hepatocytes appear as the closest model for the liver in …

Thiazolidinediones are a class of Peroxisome Proliferator Activated Receptor γ (PPARγ)
agonists that reduce insulin resistance in type 2 diabetic patients. Although no detectable …

Within the scope of developing an in vitro culture model for pharmacological research on
human liver functions, a three-dimensional multicompartment hollow fiber bioreactor proven …

Differentiation of stem cells to hepatocyte-like cells (HLCs) holds great promise for basic
research, drug and toxicological investigations, and clinical applications. There are currently …

Phthalates and other endocrine-disruptive chemicals are manufactured in large quantities
for use as plasticizers and other commercial applications, resulting in ubiquitous human …

With 7 million deaths reported annually from air pollution alone, it is evident that adverse
effects of inhaled toxicant exposures remain a major public health concern in the 21st …

Background Several glitazones (PPARγ agonists) and glitazars (dual PPARα/γ agonists)
have been developed to treat hyperglycemia and, simultaneously, hyperglycemia and …

Peroxisome proliferator chemicals (PPC) are thought to mediate their effects in rodents on
hepatocyte growth and liver cancer through the nuclear receptor peroxisome proliferator …

Efforts are put into developing toxicogenomics-based toxicity testing methods using in vitro
human cell models for improving human risk assessment/replacing animal models. Human …

Gene expression profiling has recently emerged as a promising approach to identify early
target genes and discriminate genotoxic carcinogens from non-genotoxic carcinogens and …