In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Objective To characterize the prevalence and burden of HIV-associated neurocognitive
disorder (HAND) and assess associated factors in the global population with HIV. Methods …

Neurocognitive disorders—including delirium, mild cognitive impairment and dementia—are
characterized by decline from a previously attained level of cognitive functioning. These …

Background. Infection with human immunodeficiency virus type 1 (HIV) is associated with
clinical symptoms of accelerated aging, as evidenced by the increased incidence and …

Objective: To evaluate the frequency of HIV-associated neurocognitive disorder (HAND) in
HIV+ individuals and determine whether the frequency of HAND changed over 4 years of …

Background Cerebrospinal fluid (CSF) neurofilament light chain protein (NFL) is a sensitive
marker of neuronal injury in a variety of neurodegenerative conditions, including the CNS …

The modern antiretroviral treatment of human immunodeficiency virus (HIV-1) infection has
considerably lowered the incidence of opportunistic infections. With the exception of the …

Objectives: This is a cross-sectional, observational study to determine the frequency and
associated features of HIV-associated neurocognitive disorders (HAND) in a large, diverse …

Alzheimer's disease is associated with cerebral accumulation of amyloid-β peptide and
hyperphosphorylated tau. In the past 28 years, huge efforts have been made in attempting to …