SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control

MR Cowie, M Fisher - Nature Reviews Cardiology, 2020 - nature.com
Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors are effective antidiabetic
therapies in patients with type 2 diabetes mellitus and are associated with improved …

Effects of SGLT2 inhibitors on kidney and cardiovascular function

V Vallon, S Verma - Annual review of physiology, 2021 - annualreviews.org
SGLT2 inhibitors are antihyperglycemic drugs that protect kidneys and the heart of patients
with or without type 2 diabetes and preserved or reduced kidney function from failing. The …

Sodium-glucose cotransporter 2 inhibitors and risk of hyperkalemia in people with type 2 diabetes: a meta-analysis of individual participant data from randomized …

BL Neuen, M Oshima, R Agarwal, C Arnott… - Circulation, 2022 - Am Heart Assoc
Background: Hyperkalemia increases risk of cardiac arrhythmias and death and limits the
use of renin-angiotensin-aldosterone system inhibitors and mineralocorticoid receptor …

Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial

MN Kosiborod, R Esterline, RHM Furtado… - The lancet Diabetes & …, 2021 - thelancet.com
Background COVID-19 can lead to multiorgan failure. Dapagliflozin, a SGLT2 inhibitor, has
significant protective benefits for the heart and kidney. We aimed to see whether this agent …

An overview of the cardiorenal protective mechanisms of SGLT2 inhibitors

T Salvatore, R Galiero, A Caturano, L Rinaldi… - International Journal of …, 2022 - mdpi.com
Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …

[HTML][HTML] Prescribing SGLT2 inhibitors in patients with CKD: expanding indications and practical considerations

K Yau, A Dharia, I Alrowiyti, DZI Cherney - Kidney international reports, 2022 - Elsevier
SGLT2 inhibitors have emerged as a key disease-modifying therapy to prevent the
progression of chronic kidney disease (CKD). These agents prevent decline in kidney …

Mechanisms of cardiovascular benefits of sodium glucose co-transporter 2 (SGLT2) inhibitors: a state-of-the-art review

GD Lopaschuk, S Verma - Basic to Translational Science, 2020 - jacc.org
Recent clinical trials have shown that sodium glucose co-transport 2 (SGLT2) inhibitors have
dramatic beneficial cardiovascular outcomes. These include a reduced incidence of …

Sodium–glucose cotransporter type 2 inhibitors for the treatment of type 2 diabetes mellitus

AJ Scheen - Nature reviews endocrinology, 2020 - nature.com
The management of type 2 diabetes mellitus (T2DM) is becoming increasingly complex.
Sodium–glucose cotransporter type 2 inhibitors (SGLT2is) are the newest antidiabetic …

Sodium-glucose cotransporter 2 inhibitors mechanisms of action: a review

JI Fonseca-Correa, R Correa-Rotter - Frontiers in Medicine, 2021 - frontiersin.org
Sodium-Glucose Cotransporter 2 inhibitors (SGLT2i), or gliflozins, are a group of antidiabetic
drugs that have shown improvement in renal and cardiovascular outcomes in patients with …

SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review

S Verma, JJV McMurray - Diabetologia, 2018 - Springer
Abstract Sodium–glucose cotransporter (SGLT) 2 inhibitors have been demonstrated to
reduce cardiovascular events, particularly heart failure, in cardiovascular outcome trials …