Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …

Over the recent years, much has been unraveled about the pro-inflammatory properties of
various mitochondrial molecules once they are leaving the mitochondrial compartment. On …

Carica papaya is a perennial large herbaceous plant known for diverse biological activities.
Different parts of this plant such as seeds, leaves, fruits, peels, roots, and stems have been …

Mitochondria are the critical organelles involved in various cellular functions. Mitochondrial
biogenesis is activated by multiple cellular mechanisms which require a synchronous …

C arica papaya is widely cultivated in tropical and subtropical countries and is used as food
as well as traditional medicine to treat a range of diseases. Increasing anecdotal reports of …

Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both
execute similar processes but with different cellular and molecular effects. Given the number …

Pancreatic cancer (PC), particularly its most common form, pancreatic ductal
adenocarcinoma (PDAC), is relatively rare but highly lethal. Knowledge about PC risk …

There are more than 4000 natural and synthetic molecules structurally and/or functionally
related to vitamin A. Retinoids are a class of these compounds that are structurally …

The first-line chemotherapies for patients with unresectable pancreatic cancer (PC) are 5-
fluorouracil (5-FU) and gemcitabine therapy. However, due to chemoresistance the …