We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

The facultative human pathogen Vibrio cholerae can be isolated from estuarine and aquatic
environments. V. cholerae is well recognized and extensively studied as the causative agent …

The gut microbiome is the resident microbial community of the gastrointestinal tract. This
community is highly diverse, but how microbial diversity confers resistance or susceptibility …

Covering: up to 2009 This review describes the chemistry of the bacterial biofilms including
the chemistry of their constituents and signalling compounds that mediate or inhibit the …

Increasing antibiotic resistance requires the development of new approaches to combating
infection. Virulence gene expression in vivo represents a target for antibiotic discovery that …

Cholera, a severe disease caused by Vibrio cholerae bacteria, has had a central role in the
history of infectious disease research. The cholera studies of John Snow and Robert Koch …

The cyclic dinucleotide second messenger cyclic diguanylate (c-diGMP) has been
implicated in regulation of cell surface properties in several bacterial species, including …

The human pathogen Vibrio cholerae is the causative agent of severe diarrheal disease
known as cholera. Of the more than 200 “O” serogroups of this pathogen, O1 and O139 …

Vibrio cholerae is a motile bacterium responsible for the disease cholera, and motility has
been hypothesized to be inversely regulated with virulence. We examined the transcription …

Quorum sensing negatively influences virulence gene expression in certain toxigenic Vibrio
cholerae strains. At high cell densities, the response regulator LuxO fails to reduce the …