The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Since its discovery in 2012, ferroptosis has been well characterized by the accumulation of
lipid peroxides due to the failure of glutathione-dependent antioxidant defenses. It is known …

BCL-2 family proteins, which have either pro-or anti-apoptotic activities, have been studied
intensively for the past decade owing to their importance in the regulation of apoptosis …

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …

Apoptosis, the cell-suicide programme executed by caspases, is critical for maintaining
tissue homeostasis, and impaired apoptosis is now recognized to be a key step in …

Bcl-2 family proteins regulate the release of proteins like cytochrome c from mitochondria
during apoptosis. We used cell-free systems and ultimately a vesicular reconstitution from …

Apoptosis (programmed cell death) is a cellular self-destruction mechanism that is essential
for a variety of biological events, such as developmental sculpturing, tissue homeostasis …

In order to eliminate cells that are redundant, damaged, or infected, metazoan organisms
have evolved the cell suicide mechanism termed apoptosis (Kerr et al. 1972). This genetic …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

The localization and control of Bcl-2 proteins on mitochondria is essential for the intrinsic
pathway of apoptosis. Anti-apoptotic Bcl-2 proteins reside on the outer mitochondrial …