Mesenchymal stem cells and cutaneous wound healing: current evidence and future potential

M Isakson, C De Blacam, D Whelan… - Stem cells …, 2015 - Wiley Online Library
Human skin is a remarkable organ that sustains insult and injury throughout life. The ability
of skin to expeditiously repair wounds is paramount to survival. With an aging global …

Autologous stem cell therapy: how aging and chronic diseases affect stem and progenitor cells

AY Efimenko, TN Kochegura, ZA Akopyan… - BioResearch open …, 2015 - liebertpub.com
During recent years different types of adult stem/progenitor cells have been successfully
applied for the treatment of many pathologies, including cardiovascular diseases. The …

Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations

RC Rennert, M Sorkin, M Januszyk, D Duscher… - Stem cell research & …, 2014 - Springer
Introduction Pathophysiologic changes associated with diabetes impair new blood vessel
formation and wound healing. Mesenchymal stem cells derived from adipose tissue (ASCs) …

Disturbed angiogenic activity of adipose-derived stromal cells obtained from patients with coronary artery disease and diabetes mellitus type 2

NA Dzhoyashvili, AY Efimenko, TN Kochegura… - Journal of translational …, 2014 - Springer
Background Multipotent mesenchymal stem/stromal cells (MSC) including adipose-derived
stromal cells (ADSC) have been successfully applied for cardiovascular diseases treatment …

Impact of type 2 diabetes mellitus on human bone marrow stromal cell number and phenotypic characteristics

FC Cassidy, C Shortiss, CG Murphy, SR Kearns… - International Journal of …, 2020 - mdpi.com
Human bone marrow-derived mesenchymal stromal cells (MSCs) have been investigated in
numerous disease settings involving impaired regeneration because of the crucial role they …

Mesenchymal stem cell therapy for diabetic kidney disease: a review of the studies using syngeneic, autologous, allogeneic, and xenogeneic cells

C Sávio-Silva, S Beyerstedt… - Stem Cells …, 2020 - Wiley Online Library
Diabetic kidney disease (DKD) is a microvascular complication of diabetes mellitus (DM)
and comprises multifactorial pathophysiologic mechanisms. Despite current treatment …

Deferoxamine preconditioning to restore impaired HIF‐1α‐mediated angiogenic mechanisms in adipose‐derived stem cells from STZ‐induced type 1 diabetic rats

M Mehrabani, M Najafi, T Kamarul, K Mansouri… - Cell …, 2015 - Wiley Online Library
Objectives Both excessive and insufficient angiogenesis are associated with progression of
diabetic complications, of which poor angiogenesis is an important feature. Currently …

High glucose-induced reactive oxygen species generation promotes stemness in human adipose-derived stem cells

NC Cheng, TY Hsieh, HS Lai, TH Young - Cytotherapy, 2016 - Elsevier
Background aims Adipose-derived stem cells (ASCs) represent an important source of cell
therapy to treat diabetic complications. However, hyperglycemia may alter several cellular …

Impact of type 2 diabetes mellitus on the immunoregulatory characteristics of adipose tissue-derived mesenchymal stem cells

N Abu-Shahba, M Mahmoud, AM El-Erian… - The international journal …, 2021 - Elsevier
Background Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder associated
with several complications. Adipose tissue-derived mesenchymal stem cells (AT-MSCs) …

Impact of diabetes mellitus on human mesenchymal stromal cell biology and functionality: implications for autologous transplantation

M Mahmoud, N Abu-Shahba, O Azmy… - Stem cell reviews and …, 2019 - Springer
Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and
immunomodulatory properties to restore and repair injured tissues, making them attractive …