Drug discovery and repositioning are important processes for the pharmaceutical industry.
These processes demand a high investment in resources and are time-consuming. Several …

Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma
cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions …

Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

Background: Design of small molecules which are able to bind to the protein responsible for
a disease is the key step of the entire process of the new medicine discovery. Atomistic …

Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …

Chagas disease (CD) affects at least 6 million people in 21 South American countries
besides several thousand in other nations all over the world. It is estimated that at least …

Pan-assay interference compounds (PAINS) are promiscuous compound classes that
produce false positive hits in high-throughput screenings. Yet, the mechanisms of PAINS …

Medicinal plants serve as a valuable source of secondary metabolites since time
immemorial. Computational Research in 21st century is giving more attention to medicinal …

Drug repositioning is a revolution breakthrough of drug discovery that presents outstanding
privilege with already safer agents by scanning the existing candidates as therapeutic …

Background: Parasitic diseases caused by protozoa, such as Chagas disease,
leishmaniasis, malaria, African trypanosomiasis, amoebiasis, trichomoniasis, and giardiasis …