Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Maintenance of endothelial cell integrity is an important component of human health and
disease since the endothelium can perform various functions including regulation of …

Inflammatory pathways drive atherogenesis and link conventional risk factors to
atherosclerosis and its complications. One inflammatory mediator has come to the fore as a …

Decades of research have established atherosclerosis as an inflammatory disease. Only
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti …

The remarkable plasticity and plethora of biological functions performed by macrophages
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …

Developing strategies that promote the resolution of vascular inflammation and
atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes …

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of
lipids, smooth muscle cell proliferation, cell apoptosis, necrosis, fibrosis, and local …

Objective—Smooth muscle cells (SMCs) are the most abundant cells in human
atherosclerotic lesions and are suggested to contribute at least 50% of atheroma foam cells …

Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …