Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

Long noncoding RNAs (lncRNAs) are a large and diverse class of genes in eukaryotic
genomes that contribute to a variety of regulatory processes. Functionally characterized …

RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

How the noncoding genome affects cellular functions is a key biological question. A
particular challenge is to distinguish the effects of noncoding DNA elements from long …

Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to
the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically …

RNA has long been regarded primarily as the intermediate between genes and proteins. It
was a surprise then to discover that eukaryotic genes are mosaics of mRNA sequences …

Long noncoding RNAs (lncRNAs) are products of pervasive transcription that closely
resemble messenger RNAs on the molecular level, yet function through largely unknown …

Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor
CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers …

Long non-coding RNAs (lncRNAs) constitute a poorly studied class of transcripts with
emerging roles in key cellular processes. Despite efforts to characterize lncRNAs across a …