Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc.
The interactions between these components, which are divided into anti-tumor and pro …

Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

Collagens in the extracellular matrix (ECM) provide a physical barrier to tumor immune
infiltration, while also acting as a ligand for immune inhibitory receptors. Transforming …

Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …

Background Our previous work showed that the anti-TGF-β/PD-L1 bispecific antibody
YM101 effectively overcame anti-PD-L1 resistance in immune-excluded tumor models …

In an attempt to overcome resistance to immune checkpoint inhibitors (ICI), an ever-
increasing number of trials are exploring combination treatment approaches. Outcomes of a …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

Simple Summary Immune checkpoint inhibitors (ICIs) are the most mature treatment of
immunotherapy and have changed the mode of cancer treatment. Recent studies showed …

Immunotherapy combined with antiangiogenic targeted therapy has improved the treatment
of certain solid tumors, but effective regimens remain elusive for refractory …

Colorectal cancer (CRC) is a highly heterogeneous cancer and exploring novel therapeutic
options is a pressing issue that needs to be addressed. Here, we established human CRC …