Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent,
self-renewing neoplastic cells that were first identified in hematologic tumors and soon after …

Antibiotic resistance is now considered a worldwide problem that puts public health at risk.
The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new …

Hepatocellular carcinoma (HCC) is one of the most common cancers with the highest
morbidity and mortality. It is necessary to develop new anti-liver cancer drugs. Itraconazole …

Introduction Medulloblastoma (MB) is a heterogeneous tumor of the cerebellum that is
divided into four main subgroups with distinct molecular and clinical features. Sonic …

There is increasing evidence that malignant tumors are initiated and maintained by a sub-
population of tumor cells that have similar biological properties to normal adult stem cells …

The discovery of antibiotics has revolutionized the medicine and treatment of microbial
infections. However, the current scenario has highlighted the difficulties in marketing new …

Although Cisplatin (DDP) is a widely used first-line chemotherapy medication, DDP
resistance is one of the main causes of treatment failure in advanced lung cancer. Therefore …

Abstract The Sonic Hedgehog (SHH) pathway is crucial regulator of embryonic development
and stemness. Its alteration leads to medulloblastoma (MB), the most common malignant …

ABSTRACT Introduction: Hedgehog (Hh) signaling plays a pivotal role in tissue
development and stemness, and its deregulation is found in many different tumors. Several …

Aberrant activation of Hedgehog (HH) signaling in cancer is the result of genetic alterations
of upstream pathway components (canonical) or other oncogenic mechanisms …