The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Nucleotide-binding, leucine-rich repeat receptors (NLRs) are major immune receptors in
plants and animals. Upon activation, the Arabidopsis NLR protein ZAR1 forms a pentameric …

Activity-dependent transcriptional responses shape cortical function. However, a
comprehensive understanding of the diversity of these responses across the full range of …

Biomolecular condensates organize biochemistry, yet little is known about how cells control
the position and scale of these structures. In cells, condensates often appear as relatively …

Light sheet microscopy is a powerful technique for high-speed three-dimensional imaging of
subcellular dynamics and large biological specimens. However, it often generates datasets …

Structured illumination microscopy (SIM) doubles the spatial resolution of a fluorescence
microscope without requiring high laser powers or specialized fluorophores. However, the …

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …

This brief overview of endocytic trafficking is written in honor of Renate Fuchs, who retires
this year. In the mid-1980s, Renate pioneered studies on the ion-conducting properties of …