[HTML][HTML] Small molecule-based treatment approaches for intervertebral disc degeneration: current options and future directions

A Kamali, R Ziadlou, G Lang, J Pfannkuche, S Cui… - Theranostics, 2021 - ncbi.nlm.nih.gov
Low back pain (LBP) is a major reason for disability, and symptomatic intervertebral disc
(IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases. Current treatment …

Cannabidiol, neuroprotection and neuropsychiatric disorders

AC Campos, MV Fogaça, AB Sonego… - Pharmacological …, 2016 - Elsevier
Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid derived from Cannabis
sativa. It has possible therapeutic effects over a broad range of neuropsychiatric disorders …

Intervertebral disc degeneration—Current therapeutic options and challenges

A Samanta, T Lufkin, P Kraus - Frontiers in Public Health, 2023 - frontiersin.org
Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's
declining function and the development of pain, it may affect one's physical health, mental …

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

S Suzuki, N Fujita, N Hosogane, K Watanabe… - Arthritis research & …, 2015 - Springer
Introduction Oxidative stress has been reported to be involved in numerous human
diseases, including musculoskeletal disorders such as osteoarthritis. However, the …

Molecular targets of cannabidiol in experimental models of neurological disease

S Silvestro, G Schepici, P Bramanti, E Mazzon - Molecules, 2020 - mdpi.com
Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects
including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with …

Neuroprotective and symptomatic effects of cannabidiol in an animal model of Parkinson's disease

C Giuliano, M Francavilla, G Ongari, A Petese… - International Journal of …, 2021 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopaminergic neurons in the Substantia Nigra pars compacta, leading to classical PD motor …

Cannabidiol induces autophagy via ERK1/2 activation in neural cells

TAM Vrechi, AHFF Leão, IBM Morais, VC Abílio… - Scientific reports, 2021 - nature.com
Autophagy is a lysosomal catabolic process essential to cell homeostasis and is related to
the neuroprotection of the central nervous system. Cannabidiol (CBD) is a non-psychotropic …

Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review

Z Fu, PY Zhao, XP Yang, H Li, SD Hu, YX Xu… - Frontiers in …, 2023 - frontiersin.org
Cannabidiol (CBD) is a terpenoid naturally found in plants. The purified compound is used
in the treatment of mental disorders because of its antidepressive, anxiolytic, and …

[HTML][HTML] Avicenna's Canon of Medicine: a review of analgesics and anti-inflammatory substances

S Mahdizadeh, MK Ghadiri, A Gorji - Avicenna journal of …, 2015 - ncbi.nlm.nih.gov
Naturally occurring substances mentioned in medieval medical literatures currently have,
and will continue to have, a crucial place in drug discovery. Avicenna was a Persian …

Cannabidiol protects dopaminergic neuronal cells from cadmium

JJV Branca, G Morucci, M Becatti, D Carrino… - International journal of …, 2019 - mdpi.com
The protective effect of cannabidiol (CBD), the non-psychoactive component of Cannabis
sativa, against neuronal toxicity induced by cadmium chloride (CdCl2 10 μM) was …