Uric acid and the cardio‐renal effects of SGLT2 inhibitors
CJ Bailey - Diabetes, Obesity and Metabolism, 2019 - Wiley Online Library
Sodium/glucose co‐transporter‐2 (SGLT2) inhibitors, which lower blood glucose by
increasing renal glucose elimination, have been shown to reduce the risk of adverse …
increasing renal glucose elimination, have been shown to reduce the risk of adverse …
Uric acid as a biomarker and a therapeutic target in diabetes
Y Lytvyn, BA Perkins, DZI Cherney - Canadian journal of diabetes, 2015 - Elsevier
Diabetic nephropathy is a long-standing microvascular complication of diabetes mellitus and
is the leading cause of end stage renal disease in developed countries. Current therapeutic …
is the leading cause of end stage renal disease in developed countries. Current therapeutic …
Hypertension in children: new trends and challenges
J Feber, M Ahmed - Clinical Science, 2010 - portlandpress.com
Childhood HTN (hypertension) has become a widely investigated topic within the last
decade due to its increasing prevalence. In the present review, we examine new …
decade due to its increasing prevalence. In the present review, we examine new …
Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes
Q Li, Z Yang, B Lu, J Wen, Z Ye, L Chen, M He… - Cardiovascular …, 2011 - Springer
Objective We aimed to investigate whether elevated serum uric acid concentrations are
associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in …
associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in …
Hyperuricemia induces endothelial dysfunction via mitochondrial Na+/Ca2+ exchanger-mediated mitochondrial calcium overload
BACKGROUND: Uric acid (UA) has proven to be a causal agent in endothelial dysfunction
in which ROS production plays an important role. Calcium overload in mitochondria can …
in which ROS production plays an important role. Calcium overload in mitochondria can …
Association of uric acid with vascular stiffness in the Framingham Heart Study
T Mehta, E Nuccio, K McFann, M Madero… - American journal of …, 2015 - academic.oup.com
BACKGROUND Uric acid is associated with increased risk of cardiovascular disease and
arterial stiffness in patients with hypertension or stroke. It remains unknown if uric acid is …
arterial stiffness in patients with hypertension or stroke. It remains unknown if uric acid is …
Uric acid and arterial stiffness
Hyperuricemia is usually associated with hypertension, diabetes mellitus, metabolic
syndrome and chronic kidney disease. Accumulating data from epidemiological studies …
syndrome and chronic kidney disease. Accumulating data from epidemiological studies …
Longitudinal association between serum uric acid and arterial stiffness: results from the Baltimore longitudinal study of aging
M Canepa, F Viazzi, JB Strait, P Ameri, R Pontremoli… - …, 2017 - Am Heart Assoc
Serum uric acid (SUA) has long been associated with increased cardiovascular risk, with
arterial stiffness proposed as a mediator. However, evidence on the association between …
arterial stiffness proposed as a mediator. However, evidence on the association between …
Carotid plaques from symptomatic patients are characterized by local increase in xanthine oxidase expression
Background and Purpose: XO (xanthine oxidase) is a key enzyme of uric acid metabolism
and is thought to contribute to oxidative pathways that promote atherosclerotic plaque …
and is thought to contribute to oxidative pathways that promote atherosclerotic plaque …
Uric acid: from a biological advantage to a potential danger. A focus on cardiovascular effects
Non-communicable diseases represent nowadays the most common cause of death
worldwide, having largely overcome infectious diseases. Among them, cardiovascular …
worldwide, having largely overcome infectious diseases. Among them, cardiovascular …