Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria

LJ Kiely, K Busca, JA Lane… - FEMS Microbiology …, 2023 - academic.oup.com
A number of bacterial species are found in high abundance in the faeces of healthy breast-
fed infants, an occurrence that is understood to be, at least in part, due to the ability of these …

Structure and function of microbial α-l-fucosidases: a mini review

H Wu, CD Owen, N Juge - Essays in Biochemistry, 2023 - portlandpress.com
Fucose is a monosaccharide commonly found in mammalian, insect, microbial and plant
glycans. The removal of terminal α-l-fucosyl residues from oligosaccharides and …

Linking human milk oligosaccharide metabolism and early life gut microbiota: Bifidobacteria and beyond

C Lordan, AK Roche, D Delsing, A Nauta… - Microbiology and …, 2024 - Am Soc Microbiol
Human milk oligosaccharides (HMOs) are complex, multi-functional glycans present in
human breast milk. They represent an intricate mix of heterogeneous structures which reach …

CRISPR-Cas-based identification of a sialylated human milk oligosaccharides utilization cluster in the infant gut commensal Bacteroides dorei

S Kijner, D Ennis, S Shmorak, A Florentin… - Nature …, 2024 - nature.com
The infant gut microbiome is impacted by early-life feeding, as human milk oligosaccharides
(HMOs) found in breastmilk cannot be digested by infants and serve as nutrients for their gut …

Milk oligosaccharide-driven persistence of Bifidobacterium pseudocatenulatum modulates local and systemic microbial metabolites upon synbiotic treatment in …

JA Larke, BE Heiss, AM Ehrlich, DH Taft, HE Raybould… - Microbiome, 2023 - Springer
Background Bifidobacteria represent an important gut commensal in humans, particularly
during initial microbiome assembly in the first year of life. Enrichment of Bifidobacterium is …

Early development of infant gut microbiota in relation to breastfeeding and human milk oligosaccharides

M Chichlowski, JA Van Diepen, A Prodan, L Olga… - Frontiers in …, 2023 - frontiersin.org
Background Infant gut microbiota composition is influenced by various factors early in life.
Here, we investigate associations between infant gut microbiome development, infant age …

2′-Fucosyllactose Increases the Abundance of Blautia in the Presence of Extracellular Fucosidase-Possessing Bacteria

A Horigome, N Hashikura, K Yoshida, J Xiao… - Frontiers in …, 2022 - frontiersin.org
Blautia is a genus of anaerobic bacteria that is widely distributed in the mammalian gut.
Recently, an increasing body of research has demonstrated a link between this genus and …

Recent progress in fucosylated derivatives of lacto-N-tetraose and lacto-N-neotetraose

L Yang, Y Zhu, J Meng, W Zhang… - Critical Reviews in Food …, 2023 - Taylor & Francis
Human milk oligosaccharides (HMOs) have attracted considerable attention owing to their
unique physiological functions. Two important tetrasaccharides, lacto-N-tetraose (LNT) and …

Human milk oligosaccharide utilization in intestinal Bifidobacteria is governed by global transcriptional regulator NagR

AA Arzamasov, A Nakajima, M Sakanaka, MN Ojima… - Msystems, 2022 - Am Soc Microbiol
Bifidobacterium longum subsp. infantis is a prevalent beneficial bacterium that colonizes the
human neonatal gut and is uniquely adapted to efficiently use human milk oligosaccharides …

Engineered plants provide a photosynthetic platform for the production of diverse human milk oligosaccharides

CR Barnum, B Paviani, G Couture, C Masarweh… - Nature Food, 2024 - nature.com
Human milk oligosaccharides (HMOs) are a diverse class of carbohydrates which support
the health and development of infants. The vast health benefits of HMOs have made them a …