The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …

The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as
well as the electron transporters ubiquinone and cytochrome c. There are two electron …

Mitochondria not only supply the energy for cell function, but also take part in cell signaling.
This review describes the dysfunctions of mitochondria in aging and neurodegenerative …

Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …

The ketogenic diet, originally developed for the treatment of epilepsy in non-responder
children, is spreading to be used in the treatment of many diseases, including Alzheimer's …

Brain temperature, as an independent therapeutic target variable, has received increasingly
intense clinical attention. To date, brain hypothermia represents the most potent …

Sirtuins are a conserved family of proteins found in all domains of life. The first known sirtuin,
Sir2 (silent information regulator 2) of Saccharomyces cerevisia e, from which the family …

Heat is of fundamental importance in many cellular processes such as cell metabolism, cell
division and gene expression. Accurate and noninvasive monitoring of temperature changes …