Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

I Goldstein, V Marcel, M Olivier, M Oren, V Rotter… - Cancer gene …, 2011 - nature.com
Three decades of p53 research have led to many advances in understanding the basic
biology of normal and cancer cells. Nonetheless, the detailed functions of p53 in normal …

p53's extended reach: The mutant p53 secretome

E Pavlakis, T Stiewe - Biomolecules, 2020 - mdpi.com
p53 suppresses tumorigenesis by activating a plethora of effector pathways. While most of
these operate primarily inside of cells to limit proliferation and survival of incipient cancer …

Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis

N Rivlin, R Brosh, M Oren, V Rotter - Genes & cancer, 2011 - journals.sagepub.com
Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases,
the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is …

Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells

L Nissim, SD Perli, A Fridkin, P Perez-Pinera, TK Lu - Molecular cell, 2014 - cell.com
RNA-based regulation and CRISPR/Cas transcription factors (CRISPR-TFs) have the
potential to be integrated for the tunable modulation of gene networks. A major limitation of …

p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner

A Molchadsky, I Shats, N Goldfinger… - PloS one, 2008 - journals.plos.org
Background The tumor suppressor p53 is an important regulator that controls various
cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 …

A tunable dual‐promoter integrator for targeting of cancer cells

L Nissim, RH Bar‐Ziv - Molecular systems biology, 2010 - embopress.org
Precise discrimination between similar cellular states is essential for autonomous decision‐
making scenarios, such as in vivo targeting of diseased cells. Discrimination could be …

p53‐repressed miRNAs are involved with E2F in a feed‐forward loop promoting proliferation

R Brosh, R Shalgi, A Liran, G Landan… - Molecular systems …, 2008 - embopress.org
Normal cell growth is governed by a complicated biological system, featuring multiple levels
of control, often deregulated in cancers. The role of microRNAs (miRNAs) in the control of …

Genome‐wide transcriptome analyses reveal p53 inactivation mediated loss of miR‐34a expression in malignant peripheral nerve sheath tumours

S Subramanian, V Thayanithy, RB West… - The Journal of …, 2010 - Wiley Online Library
Malignant peripheral nerve sheath tumours (MPNSTs) are aggressive soft tissue tumours
that occur either sporadically or in patients with neurofibromatosis type 1. The malignant …

Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival

DR Bublik, S Bursać, M Sheffer… - Proceedings of the …, 2017 - National Acad Sciences
The microRNA miR-504 targets TP53 mRNA encoding the p53 tumor suppressor. miR-504
resides within the fibroblast growth factor 13 (FGF13) gene, which is overexpressed in …

Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

H Solomon, Y Buganim, I Kogan-Sakin… - Journal of cell …, 2012 - journals.biologists.com
Concomitant expression of mutant p53 and oncogenic Ras, leading to cellular
transformation, is well documented. However, the mechanisms by which the various mutant …