Biosynthesis and biology of mammalian GPI-anchored proteins
T Kinoshita - Open biology, 2020 - royalsocietypublishing.org
At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs).
The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma …
The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma …
Post-translational modifications of the protein termini
Post-translational modifications (PTM) involve enzyme-mediated covalent addition of
functional groups to proteins during or after synthesis. These modifications greatly increase …
functional groups to proteins during or after synthesis. These modifications greatly increase …
Structure-guided isoform identification for the human transcriptome
Recently developed methods to predict three-dimensional protein structure with high
accuracy have opened new avenues for genome and proteome research. We explore a new …
accuracy have opened new avenues for genome and proteome research. We explore a new …
Congenital disorders of glycosylation from a neurological perspective
J Paprocka, A Jezela-Stanek, A Tylki-Szymańska… - Brain Sciences, 2021 - mdpi.com
Most plasma proteins, cell membrane proteins and other proteins are glycoproteins with
sugar chains attached to the polypeptide-glycans. Glycosylation is the main element of the …
sugar chains attached to the polypeptide-glycans. Glycosylation is the main element of the …
Diagnostic yield of whole genome sequencing after nondiagnostic exome sequencing or gene panel in developmental and epileptic encephalopathies
Objective To assess the benefits and limitations of whole genome sequencing (WGS)
compared to exome sequencing (ES) or multigene panel (MGP) in the molecular diagnosis …
compared to exome sequencing (ES) or multigene panel (MGP) in the molecular diagnosis …
Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis
Glycosylphosphatidylinositols (GPIs) are complex glycolipids that act as membrane anchors
of many eukaryotic cell surface proteins. Biosynthesis of GPIs is initiated at the cytosolic face …
of many eukaryotic cell surface proteins. Biosynthesis of GPIs is initiated at the cytosolic face …
The glycosylphosphatidylinositol anchor: a linchpin for cell surface versatility of trypanosomatids
The use of glycosylphosphatidylinositol (GPI) to anchor proteins to the cell surface is
widespread among eukaryotes. The GPI-anchor is covalently attached to the C-terminus of a …
widespread among eukaryotes. The GPI-anchor is covalently attached to the C-terminus of a …
A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins
SS Liu, YS Liu, XY Guo, Y Murakami, G Yang… - Communications …, 2021 - nature.com
Over 100 kinds of proteins are expressed as glycosylphosphatidylinositol (GPI)-anchored
proteins (GPI-APs) on the cell surface in mammalian cells. GPI-APs possess unique …
proteins (GPI-APs) on the cell surface in mammalian cells. GPI-APs possess unique …
Lessons learned from 40 novel PIGA patients and a review of the literature
Objective To define the phenotypic spectrum of phosphatidylinositol glycan class A protein
(PIGA)‐related congenital disorder of glycosylation (PIGA‐CDG) and evaluate genotype …
(PIGA)‐related congenital disorder of glycosylation (PIGA‐CDG) and evaluate genotype …
Mammalian GPI-anchor modifications and the enzymes involved
YS Liu, M Fujita - Biochemical Society Transactions, 2020 - portlandpress.com
Glycosylphosphatidylinositol (GPI) is a glycolipid added to the C-terminus of a large variety
of proteins in eukaryotes, thereby anchoring these proteins to the cell surface. More than …
of proteins in eukaryotes, thereby anchoring these proteins to the cell surface. More than …