Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Nearly all human complex traits and disease phenotypes exhibit some degree of sex
differences, including differences in prevalence, age of onset, severity or disease …

Males and females present differences in complex traits and in the risk of a wide array of
diseases. Genotype by sex (GxS) interactions are thought to account for some of these …

Many psychiatric disorders exhibit sex differences, but the underlying mechanisms remain
poorly understood. We analyzed transcriptomics data from 2160 postmortem adult prefrontal …

Obesity is a worldwide epidemic, with major health and economic costs. Here we estimate
heritability for body mass index (BMI) in 172,000 sibling pairs and 150,832 unrelated …

Psychiatric disorders are highly genetically correlated, but little research has been
conducted on the genetic differences between disorders. We developed a new method …

Sex differences in body fat distribution, glucose homeostasis, insulin signaling, ectopic fat
accumulation, and lipid metabolism during normal growth and in response to hormonal or …

Phenotypic sex-based differences exist for many complex traits. In other cases, phenotypes
may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are …

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that predominantly affects
the axial skeleton, although it can affect peripheral joints, and extra-musculoskeletal …

Neurological and neuropsychiatric disorders affect men and women differently. Multiple
sclerosis, Alzheimer's disease, anxiety disorders, depression, meningiomas and late-onset …