Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

Amyotrophic lateral sclerosis (ALS) is a fatal late onset neurological disorder characterized
by motor neuron degeneration in the primary motor cortex, brainstem and spinal cord. The …

Mutations in VCP have been reported to account for a spectrum of phenotypes that include
inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia …

Clinical severity and treatment response vary significantly between patients with spinal
muscular atrophy. The approval of therapies and the emergence of neonatal screening …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by the degeneration of motor neurons. Genetic factors play a key role in ALS …

Background The study of epigenetic processes and mechanisms present a dynamic
approach to assess complex individual variation in obesity susceptibility. However, few …

Amyotrophic lateral sclerosis (ALS) is a progressive fatal multisystemic neurodegenerative
disorder caused by preferential degeneration of upper and lower motor neurons. To further …

Abnormal expansion of a hexanucleotide GGGGCC repeat in the C9orf72 gene is the most
common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia in …

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease
characterized by the degeneration of the motor neurons. To date, 126 genes have been …

Neurodegenerative diseases are one of the greatest medical burdens of the modern age,
being mostly incurable and with limited prognostic and diagnostic tools. Amyotrophic lateral …