Abstract Factor XIa (FXIa) is a serine protease homodimer that belongs to the intrinsic
coagulation pathway. FXIa primarily catalyzes factor IX activation to factor IXa, which …

Tissue factor pathway inhibitor-2 (TFPI-2) is a 32 kDa matrix-associated Kunitz-type serine
proteinase inhibitor consisting of a short amino-terminal region, three tandem Kunitz-type …

Growing evidence suggests that plasmin is involved in a number of physiological processes
in addition to its key role in fibrin cleavage. Plasmin inhibition is critical in preventing …

Background Tissue factor pathway inhibitor-2 (TFPI-2) is a matrix-associated Kunitz inhibitor
that inhibits plasmin and trypsin-mediated activation of zymogen matrix metalloproteinases …

Background Diabetes mellitus is one of the causes of poor ventricular remodelling and poor
cardiac recovery after myocardial infarction (MI). We previously reported that tissue factor …

Objective—The purpose of this study is to investigate the expression and regulation of type-
2 tissue factor pathway inhibitor (TFPI-2) in endothelial cells, as well as the regulation of …

Background The purpose of this study is to evaluate the prognostic value of TFPI-2
expression in breast cancer patients through examining the correlation between TFPI-2 …

Sepsis is characterized by a dysregulated host-pathogen response, leading to high cytokine
levels, excessive coagulation and failure to eradicate invasive bacteria. Novel therapeutic …

Abstract Tissue Factor Pathway Inhibitor-2 (TFPI-2) is a potent inhibitor of plasmin which
activates metalloproteinases (MMPs) involved in extracellular matrix (ECM) degradation. Its …

Diabetes mellitus (DM) promotes neointimal hyperplasia, characterized by dysregulated
proliferation and accumulation of vascular smooth muscle cells (VSMCs), leading to …