The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

In this review we examine the effects of both over-and under-production of heme oxygenase-
1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular …

Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …

In recent years, the heme catabolic pathway is considered to play an important regulatory
role in cell protection, apoptosis, inflammation, and other physiological and pathological …

Heme is a complex of iron and the tetrapyrrole protoporphyrin IX with essential functions in
aerobic organisms. Heme is the prosthetic group of hemoproteins such as hemoglobin and …

The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic
syndrome. This review reflects the dramatic increase in research on the role of increased …

Purpose Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
inflammasome is important in inflammation of several diabetic complications. However, the …

Significance: Many physiological effects of natural antioxidants, their extracts or their major
active components, have been reported in recent decades. Most of these compounds are …

Objective Obese leptin deficient (ob/ob) mice are a model of adiposity that displays
increased levels of fat, glucose, and liver lipids. Our hypothesis is that HO‐1 overexpression …

Diabetes-induced vascular disorder is considered one of the deadly risk factors among
diabetic patients that are caused by persistent hyperglycemia that eventually leads to …