Heme oxygenase-1: an anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders
SW Ryter - Antioxidants, 2022 - mdpi.com
The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …
HO-1 overexpression and underexpression: Clinical implications
GS Drummond, J Baum, M Greenberg, D Lewis… - Archives of biochemistry …, 2019 - Elsevier
In this review we examine the effects of both over-and under-production of heme oxygenase-
1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular …
1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular …
Lipid nanoparticles for nucleic acid delivery to endothelial cells
GW Liu, EB Guzman, N Menon, RS Langer - Pharmaceutical Research, 2023 - Springer
Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …
Heme catabolic pathway in inflammation and immune disorders
B Wu, Y Wu, W Tang - Frontiers in pharmacology, 2019 - frontiersin.org
In recent years, the heme catabolic pathway is considered to play an important regulatory
role in cell protection, apoptosis, inflammation, and other physiological and pathological …
role in cell protection, apoptosis, inflammation, and other physiological and pathological …
Heme as a target for therapeutic interventions
S Immenschuh, V Vijayan, S Janciauskiene… - Frontiers in …, 2017 - frontiersin.org
Heme is a complex of iron and the tetrapyrrole protoporphyrin IX with essential functions in
aerobic organisms. Heme is the prosthetic group of hemoproteins such as hemoglobin and …
aerobic organisms. Heme is the prosthetic group of hemoproteins such as hemoglobin and …
Translational significance of heme oxygenase in obesity and metabolic syndrome
NG Abraham, JM Junge, GS Drummond - Trends in pharmacological …, 2016 - cell.com
The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic
syndrome. This review reflects the dramatic increase in research on the role of increased …
syndrome. This review reflects the dramatic increase in research on the role of increased …
Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model
B Luo, B Li, W Wang, X Liu, X Liu, Y Xia… - … drugs and therapy, 2014 - Springer
Purpose Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
inflammasome is important in inflammation of several diabetic complications. However, the …
inflammasome is important in inflammation of several diabetic complications. However, the …
Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases
I Barbagallo, F Galvano, A Frigiola… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Many physiological effects of natural antioxidants, their extracts or their major
active components, have been reported in recent decades. Most of these compounds are …
active components, have been reported in recent decades. Most of these compounds are …
Retracted: Increased HO‐1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21
TD Hinds Jr, K Sodhi, C Meadows, L Fedorova, N Puri… - …, 2014 - Wiley Online Library
Objective Obese leptin deficient (ob/ob) mice are a model of adiposity that displays
increased levels of fat, glucose, and liver lipids. Our hypothesis is that HO‐1 overexpression …
increased levels of fat, glucose, and liver lipids. Our hypothesis is that HO‐1 overexpression …
The role of polyphenol in modulating associated genes in diabetes-induced vascular disorders
Diabetes-induced vascular disorder is considered one of the deadly risk factors among
diabetic patients that are caused by persistent hyperglycemia that eventually leads to …
diabetic patients that are caused by persistent hyperglycemia that eventually leads to …