[HTML][HTML] Global spread of carbapenem-resistant Enterobacteriaceae: Epidemiological features, resistance mechanisms, detection and therapy

J Ma, X Song, M Li, Z Yu, W Cheng, Z Yu… - Microbiological …, 2023 - Elsevier
Bacterial drug resistance has become a global public health threat, among which the
infection of carbapenem-resistant Enterobacterales (CRE) is one of the top noticeable …

Efficacy of phage therapy in preclinical models of bacterial infection: a systematic review and meta-analysis

SA Gomez-Ochoa, M Pitton, LG Valente… - The Lancet …, 2022 - thelancet.com
Background Antimicrobial resistance of bacterial pathogens is an increasing clinical
problem and alternative approaches to antibiotic chemotherapy are needed. One of these …

Phage therapy: an alternative treatment modality for MDR bacterial infections

N Pal, P Sharma, M Kumawat, S Singh… - Infectious …, 2024 - Taylor & Francis
The increasing global incidence of multidrug-resistant (MDR) bacterial infections threatens
public health and compromises various aspects of modern medicine. Recognising the …

Pharmacokinetics and pharmacodynamics of a novel virulent Klebsiella phage Kp_Pokalde_002 in a mouse model

G Dhungana, R Nepal, M Regmi… - Frontiers in Cellular and …, 2021 - frontiersin.org
Phage therapy is one of the most promising alternatives to antibiotics as we face global
antibiotic resistance crisis. However, the pharmacokinetics (PK) and pharmacodynamics …

Phage therapy for mosquito larval control: a proof-of-principle study

CV Tikhe, G Dimopoulos - MBio, 2022 - Am Soc Microbiol
The mosquito microbiota has a profound impact on multiple biological processes ranging
from reproduction to disease transmission. Interestingly, the adult mosquito microbiota is …

Phage therapy: a revolutionary shift in the management of bacterial infections, pioneering new horizons in clinical practice, and reimagining the arsenal against …

SL Karn, M Gangwar, R Kumar, SK Bhartiya… - Frontiers in …, 2023 - frontiersin.org
The recent approval of experimental phage therapies by the FDA and other regulatory
bodies with expanded access in cases in the United States and other nations caught the …

Genomic characterization of three bacteriophages targeting multidrug resistant clinical isolates of Escherichia, Klebsiella and Salmonella

R Nepal, G Houtak, S Karki, G Dhungana… - Archives of …, 2022 - Springer
Application of bacteriophages (phages) to treat complex multidrug-resistant bacterial
infection is gaining traction because of its efficacy and universal availability. However, as …

Preclinical characterization and in silico safety assessment of three virulent bacteriophages targeting carbapenem-resistant uropathogenic Escherichia coli

G Dhungana, R Nepal, G Houtak, G Bouras… - International …, 2024 - Springer
Phage therapy has recently been revitalized in the West with many successful applications
against multi-drug-resistant bacterial infections. However, the lack of geographically diverse …

Isolation and characterization of lytic bacteriophage against multi-drug resistant Pseudomonas aeruginosa

A Maharjan, R Nepal, G Dhungana, A Parajuli… - 2021 - elibrary.nhrc.gov.np
Background: Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen
frequently causing healthcare-associated infections. The apocalyptic rise of antimicrobial …

Phages for treatment of Klebsiella pneumoniae infections

BM Zaki, AH Hussein, TA Hakim, MS Fayez… - Progress in Molecular …, 2023 - Elsevier
Klebsiella pneumoniae is an opportunistic pathogen involved in both hospital-and
community-acquired infections. K. pneumoniae is associated with various infections …