Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

Filamentous fungi constitute a large group of eukaryotic microorganisms that grow by
forming simple tube-like hyphae that are capable of differentiating into more-complex …

The localization of mRNAs to subcellular compartments provides a mechanism for
regulating gene expression with exquisite temporal and spatial control. Recent studies …

RNA localization contributes to cell polarity and synaptic plasticity. Evidence will be
discussed that RNA transport and local translation in neurons may be more intimately linked …

Cells use molecular motors, such as myosins, to move, position and segregate their
organelles. Class V myosins possess biochemical and structural properties that should …

Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

Eukaryotic cells from neurons and epithelial cells to unicellular fungi frequently rely on
cellular appendages such as axons, dendritic spines, cilia, and buds for their biology. The …

The classical secretion of soluble proteins and transport of integral membrane proteins to
the cell surface require transit into and through the endoplasmic reticulum and the Golgi …

The importance of subcellular mRNA localization is well established, but the underlying
mechanisms mostly remain an enigma. Early studies suggested that specific mRNA …