In smooth muscle, Ca2+ regulates cell division, growth and cell death as well as providing
the main trigger for contraction. Ion channels provide the major access route to elevate the …

The luminal Ca2+ regulation of cardiac ryanodine receptor (RyR2) was explored at the
single channel level. The luminal Ca2+ and Mg2+ sensitivity of single CSQ2-stripped and …

Physiological muscle contraction requires an intact ligand gating mechanism of the
ryanodine receptor 1 (RyR1), the Ca2+-release channel of the sarcoplasmic reticulum …

The effect of natural phenol derivatives was studied on skeletal type sarcoplasmic reticulum
Ca 2+-ATPase and ryanodine receptor. The majority of the tested derivatives exerted …

Abstract Sarcoplasmic reticulum (SR) Ca 2+ release in striated muscle is mediated by a
multiprotein complex that includes the ryanodine receptor (RyR) Ca 2+ channel and the intra …

In mammalian skeletal muscle, the propagation of surface membrane depolarization into the
interior of the muscle fibre along the transverse (T) tubular network is essential for the …

In multiple biological systems, vital intracellular signaling processes occur locally in minute
periplasmic subspaces often referred to as signaling microdomains. The number of …

Magnesium-induced inhibition of the skeletal ryanodine receptor/calcium-release channel
(RyR) was studied in the presence and absence of ATP under isolated conditions and in …

The effect of gadolinium ions on the sarcoplasmic reticulum (SR) calcium release
channel/ryanodine receptor (RyR1) was studied using heavy SR (HSR) vesicles and RyR1 …

Ca 2+ regulates ryanodine receptor's (RyR) activity through an activating and an inhibiting
Ca 2+-binding site located on the cytoplasmic side of the RyR channel. Their altered …